https://stream.echo6.co/videos/watch/07fb34d5-80f0-46bd-9ea0-56de8089762c Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy presents a comprehensive overview of the Regulation of Glycogen Metabolism, tying together how the body balances glycogenesis and glycogenolysis to maintain glucose homeostasis under various physiologic states. This lecture emphasizes the dynamic control exerted by hormones, intracellular signaling pathways, and allosteric regulators across liver and muscle tissue. We begin by outlining the two key enzymes—glycogen synthase and glycogen phosphorylase—and how their activity is reciprocally controlled through phosphorylation and dephosphorylation. You’ll learn how insulin promotes glycogenesis by activating protein phosphatase-1, while glucagon and epinephrine stimulate glycogenolysis through cAMP, protein kinase A (PKA), and phosphorylase kinase cascades. The lecture distinguishes between liver and skeletal muscle regulation, highlighting how the liver responds to blood glucose levels to serve the whole body, while muscle regulation is tailored to local energy demands, especially during exercise. We also explore how allosteric modulators like AMP, ATP, and glucose-6-phosphate fine-tune enzyme activity based on cellular energy status. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #GlycogenMetabolism #Metabolism Wed, 15 Apr 2026 13:41:38 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/07fb34d5-80f0-46bd-9ea0-56de8089762c All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.