https://stream.echo6.co/videos/watch/0aad6a19-fa98-4478-894d-d8b8898022a0 Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this endocrine physiology lecture, Professor Zach Murphy walks you through the complex yet beautifully orchestrated process behind the synthesis of thyroid hormone. This lecture emphasizes the essential steps that occur within the thyroid follicular cells and colloid, highlighting the roles of iodine, thyroglobulin, and key enzymes in producing T3 (triiodothyronine) and T4 (thyroxine). We begin with the active uptake of iodide via the sodium-iodide symporter (NIS), followed by its oxidation to iodine by thyroid peroxidase (TPO). From there, the lecture breaks down organification, coupling of iodotyrosine residues (MIT and DIT), and the formation of T3 and T4, which are then stored in the colloid and later released into circulation via endocytosis and proteolysis. You’ll also learn how this entire process is tightly regulated by TSH from the anterior pituitary and how negative feedback from circulating thyroid hormones maintains hormonal balance. The lecture connects these molecular events to clinically important pharmacologic agents—like thioamides (e.g., propylthiouracil, methimazole)—that target key steps in hormone synthesis. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #ThyroidHormone #Endocrinology Mon, 13 Apr 2026 20:45:43 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/0aad6a19-fa98-4478-894d-d8b8898022a0 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.