https://stream.echo6.co/videos/watch/2b1ba414-b166-4674-97c6-6139fad854f0 Premium Member Resources: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy breaks down Hepatitis E with a clear, high-yield approach focused on recognition, diagnosis, and management. This video builds a practical framework for understanding how Hepatitis E presents as an acute viral hepatitis and the key scenarios where it becomes clinically dangerous. We begin with epidemiology and transmission, emphasizing the fecal-oral route through contaminated water and food, especially in travel and outbreak settings. Zach then walks through the pathophysiology, highlighting the immune-mediated hepatocyte injury that leads to the classic progression from a prodrome to jaundice. Next, the lecture covers clinical presentation and diagnosis, focusing on the typical pattern of fatigue, nausea, myalgias, followed by jaundice, dark urine, and right upper quadrant discomfort. You will learn how to recognize the hepatocellular injury pattern on labs, rule out biliary obstruction with imaging, and confirm the diagnosis with Hepatitis E serologies. The session then focuses on high-yield complications, particularly the increased risk of acute liver failure in pregnant patients and the potential for chronic infection in immunosuppressed individuals. Finally, Zach reviews management and prevention, including supportive care for acute disease, treatment considerations in chronic infection, and key public health strategies. Enjoy the lecture, and please support us below! Table of Contents: 0:00 Lab 1:32 Etiology, Transmission and Pathophysiology of Hepatitis E 25:28 Classic Findings of Prodrome Phase 37:00 Classic Findings of Icteric Phase 45:36 Acute Liver Failure 50:50 Chronic Hepatitis E 58:10 Diagnostic Approach to Hepatitis E 1:06:12 Treatment Approach to Hepatitis E 1:07:45 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #infectiousdisease #hepatitisE Wed, 17 Jun 2026 19:19:52 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/2b1ba414-b166-4674-97c6-6139fad854f0 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.