https://stream.echo6.co/videos/watch/32606a58-d361-4fcd-a8f7-8f0969d04cef Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this endocrine physiology lecture, Professor Zach Murphy explores the function of glucagon, a vital hormone produced by the alpha cells of the pancreatic islets. This lecture focuses on how glucagon helps maintain glucose homeostasis, particularly during fasting states, by acting as a powerful counter-regulatory hormone to insulin. We begin by discussing the stimuli for glucagon release, including hypoglycemia, high amino acid levels, and sympathetic stimulation. From there, the lecture breaks down glucagon’s primary actions in the liver, where it promotes glycogenolysis, gluconeogenesis, and ketogenesis to raise blood glucose and provide energy during times of nutrient deprivation. You’ll also learn how glucagon signaling through G protein-coupled receptors and cAMP second messenger pathways allows for rapid enzymatic activation and metabolic adaptation. We highlight its minor effects on lipolysis and protein metabolism, and discuss how glucagon fits into the broader hormonal landscape during the fed vs. fasting state. Minor correction 7:16 — I referred to CCK and secretin as glucagon stimulators, but they are actually glucagon inhibitors, as they are released during the fed state. CCK and secretin are insulin stimulators due to their role in lowering blood glucose levels. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #Glucagon #Pancreas Wed, 15 Apr 2026 15:28:39 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/32606a58-d361-4fcd-a8f7-8f0969d04cef All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.