https://stream.echo6.co/videos/watch/4e7e3ce5-acd1-4605-939a-25cb039bc2de Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this endocrine physiology lecture, Professor Zach Murphy delivers an in-depth explanation of Cortisol, the body’s primary glucocorticoid hormone produced by the zona fasciculata of the adrenal cortex. This session unpacks cortisol’s essential roles in metabolism, immune modulation, and the stress response, tying together its effects across multiple organ systems. We begin with the hypothalamic-pituitary-adrenal (HPA) axis, detailing how CRH from the hypothalamus stimulates ACTH release from the anterior pituitary, which in turn promotes cortisol synthesis and secretion from the adrenal cortex. You’ll learn how cortisol exerts negative feedback on both the hypothalamus and pituitary to tightly regulate its levels. The lecture explores cortisol’s metabolic effects, including promotion of gluconeogenesis, lipolysis, and protein catabolism, alongside its anti-inflammatory and immunosuppressive actions via inhibition of cytokine production and leukocyte migration. We also examine cortisol’s permissive effects on vascular tone, catecholamine sensitivity, and bone metabolism. Clinical relevance is woven throughout with discussion of conditions such as Cushing syndrome, Addison disease, and the physiologic stress response in critical illness, surgery, or infection. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #Cortisol #AdrenalGland Mon, 13 Apr 2026 17:42:59 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/4e7e3ce5-acd1-4605-939a-25cb039bc2de All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.