https://stream.echo6.co/videos/watch/5fe7b25c-c253-4296-bac5-d5218fc4b2da Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this cardiovascular pharmacology lecture, Professor Zach Murphy delivers a comprehensive breakdown of Warfarin. This widely used oral anticoagulant plays a central role in preventing and treating thromboembolic disorders. We begin by exploring Warfarin’s mechanism of action—inhibiting vitamin K epoxide reductase (VKOR)—which disrupts the hepatic synthesis of vitamin K–dependent clotting factors II, VII, IX, and X, as well as proteins C and S. You’ll learn how this anticoagulant effect is delayed and requires careful monitoring due to its narrow therapeutic index. The lecture covers key clinical uses, including atrial fibrillation, venous thromboembolism (VTE), mechanical heart valves, and stroke prevention. It also discusses the importance of INR monitoring to adjust dosing and minimize the risk of bleeding. We also cover Warfarin’s numerous drug and dietary interactions, CYP450 metabolism, and genetic variability (CYP2C9, VKORC1) that influence patient response. Finally, we discuss reversal strategies using vitamin K, fresh frozen plasma, or prothrombin complex concentrate (PCC) in bleeding or urgent surgery. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #Warfarin #pharmacology Wed, 15 Apr 2026 15:43:15 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/5fe7b25c-c253-4296-bac5-d5218fc4b2da All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.