https://stream.echo6.co/videos/watch/6323b305-4692-49ef-9124-c26026f97689 Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy presents a detailed overview of the Urea Cycle, the body’s essential pathway for detoxifying ammonia and safely excreting nitrogen as urea. This lecture ties together amino acid catabolism and nitrogen metabolism by walking through each enzymatic step involved in the conversion of toxic nitrogen into a water-soluble waste product. We begin with the oxidative deamination of glutamate, which releases free ammonia into the mitochondria. From there, you’ll learn how carbamoyl phosphate synthetase I (CPS I) initiates the cycle, followed by a stepwise breakdown of each major enzyme and intermediate—ornithine, citrulline, argininosuccinate, arginine, and urea. The role of aspartate, ATP, and mitochondrial vs cytosolic compartments are clearly emphasized to reinforce mechanistic understanding. CORRECTION 09:00 Step 1 of the Urea Cycle should correctly state: NH₃ + HCO₃⁻ + 2 ATP → Carbamoyl phosphate (Not NH₄⁺ + 2 HCO₃⁻ + ATP as mentioned in the video.) This lecture also explores the energetic cost of the cycle, regulatory factors like N-acetylglutamate, and the clinical consequences of urea cycle disorders, including hyperammonemia and its neurologic manifestations. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #UreaCycle #Metabolism Mon, 13 Apr 2026 20:43:17 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/6323b305-4692-49ef-9124-c26026f97689 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.