https://stream.echo6.co/videos/watch/7133466f-83d0-4ab7-ba16-099751f76224 Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy walks you step-by-step through Glycolysis, the central metabolic pathway that breaks down glucose into pyruvate while generating ATP and NADH. This lecture builds a solid biochemical foundation for understanding energy production in both aerobic and anaerobic conditions, and it sets the stage for deeper dives into the citric acid cycle, oxidative phosphorylation, and beyond. We begin by outlining the ten enzymatic steps of glycolysis, from the phosphorylation of glucose by hexokinase to the final conversion of phosphoenolpyruvate to pyruvate via pyruvate kinase. Key regulatory enzymes—hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase—are highlighted, including how they respond to energy status and hormonal signals to control the pathway’s rate. The lecture also distinguishes between the energy investment phase and the energy payoff phase, showing how ATP is consumed and then generated along with the production of NADH. We emphasize the importance of glycolysis in various tissue types—especially RBCs, muscle, and cancer cells—and discuss how it functions under both aerobic and anaerobic conditions. Enjoy the lecture and support us below! Table of Contents: 00:00 Lab 01:29 Glucose (Glut) Transporters 06:30 Glucose-6-Phosphate 10:20 Fructose-6-Phosphate 11:40 Fructose-1,6-biphosphate 14:00 Dihydroxy Acetone Phosphate / Glyceraldehyde-3-Phosphate 17:24 1,3-biphosphoglycerate 20:30 3-phosphoglycerate 22:30 2-phosphoglycerate 23:40 Phosphoenol-pyruvate (PEP) 25:25 Pyruvate Kinase 27:10 Anaerobic 30:55 Comment, Like SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #Glycolysis #Metabolism Mon, 13 Apr 2026 20:43:56 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/7133466f-83d0-4ab7-ba16-099751f76224 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.