Metabolism | Regulation of the Transition Stage https://stream.echo6.co/videos/watch/8363761a-57ab-45a5-abbe-d0e9d6dc62ee Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy focuses on the Regulation of the Transition Stage—the critical control point that governs the conversion of pyruvate to acetyl-CoA via the pyruvate dehydrogenase complex (PDC). This phase determines whether carbohydrates proceed toward full oxidative metabolism or are diverted into alternative pathways, making its regulation essential for metabolic flexibility. We begin by reviewing the pyruvate dehydrogenase complex itself and how its activity is influenced by energy status, substrate availability, and hormonal control. You’ll learn how high levels of acetyl-CoA, NADH, and ATP inhibit the complex, while pyruvate, NAD⁺, and ADP act as activators, helping the cell adapt to fed or fasting states. The lecture emphasizes covalent regulation through PDH kinase, which phosphorylates and inactivates the enzyme, and PDH phosphatase, which reactivates it. We discuss how hormones such as insulin activate PDH in well-fed states, promoting acetyl-CoA formation for entry into the TCA cycle or fatty acid synthesis, especially in liver and adipose tissue. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #RegulationofTransitionStage #Metabolism Wed, 15 Apr 2026 11:48:21 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co Metabolism | Regulation of the Transition Stage https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/8363761a-57ab-45a5-abbe-d0e9d6dc62ee All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.