Thiazide Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications https://stream.echo6.co/videos/watch/8dcacad2-78df-4a90-b0e6-0c195754099f Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this pharmacology lecture, Professor Zach Murphy provides a high-yield breakdown of Thiazide Diuretics, focusing on their mechanism of action, clinical uses, and side effect profile in the management of cardiovascular and renal conditions. We begin by reviewing how thiazides—such as hydrochlorothiazide, chlorthalidone, and metolazone—inhibit the Na⁺/Cl⁻ symporter in the distal convoluted tubule, promoting sodium and water excretion while enhancing calcium reabsorption. This results in a sustained reduction in blood volume and peripheral resistance, making thiazides a first-line treatment for hypertension. The lecture explores additional indications including heart failure (mild fluid overload), nephrolithiasis (calcium stones), and nephrogenic diabetes insipidus, while also highlighting their use in combination with other antihypertensives. We then cover important side effects: hypokalemia, hyponatremia, hyperuricemia, hyperglycemia, hyperlipidemia, and metabolic alkalosis—as well as how thiazides are less effective in patients with advanced renal failure. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #ThiazideDiuretics #Diuretics Mon, 13 Apr 2026 16:58:21 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co Thiazide Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/8dcacad2-78df-4a90-b0e6-0c195754099f All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.