https://stream.echo6.co/videos/watch/a40e6333-7c2a-42f6-8025-2af56e4c1556 Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this neuropathology lecture, Professor Zach Murphy explains Acute Disseminated Encephalomyelitis (ADEM), a rare but important demyelinating disease of the central nervous system that typically follows viral infections or vaccinations, especially in children and young adults. This lecture connects the clinical features and pathophysiology of ADEM to diagnostic strategies and treatment approaches that are critical for rapid recognition and management. We begin by reviewing the immune-mediated pathogenesis of ADEM, which involves a widespread, monophasic inflammatory response targeting CNS myelin, triggered by molecular mimicry after systemic immune stimulation. You’ll learn how ADEM differs from multiple sclerosis, with a more acute onset, often following a prodromal illness, and with more encephalopathy, fever, and multifocal neurologic deficits at presentation. The lecture explains the characteristic MRI findings, including bilateral, asymmetric, poorly demarcated lesions in the white matter and sometimes gray matter that help distinguish ADEM from MS. We also cover how to interpret CSF findings and when to consider alternative diagnoses such as viral encephalitis, MS, or neuromyelitis optica. Management is centered around high-dose corticosteroids, with IVIG or plasmapheresis as second-line options in steroid-resistant cases. Prognosis is generally favorable with prompt treatment, especially in pediatric populations, though recurrence and long-term deficits can occasionally occur. Enjoy the lecture and support us below! Table of Contents: 0:00 Lab 0:31 Etiology and Pathophysiology 12:59 Clinical Features 22:55 Diagnosis 27:05 Treatment 31:31 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #ADEM #neuro Mon, 13 Apr 2026 12:48:55 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/a40e6333-7c2a-42f6-8025-2af56e4c1556 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.