https://stream.echo6.co/videos/watch/a429354a-9165-46a6-b36c-1517e8b3665e Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy presents a focused breakdown of the Regulation of the Pentose Phosphate Pathway (PPP), helping you understand how this essential metabolic route is fine-tuned to meet cellular demands for NADPH and ribose-5-phosphate. This session builds on your understanding of the pathway’s structure and emphasizes how different metabolic states influence its direction and activity. We begin by reviewing the key regulatory enzyme, glucose-6-phosphate dehydrogenase (G6PD), and how its activity is tightly controlled by the ratio of NADP⁺ to NADPH. You’ll learn that high levels of NADPH inhibit G6PD, limiting the oxidative phase, while low NADPH—seen in states of oxidative stress or active biosynthesis—activates the pathway. The role of insulin in upregulating G6PD expression during the fed state is also highlighted. Next, we examine how the non-oxidative phase adapts to cellular needs: when the demand is high for nucleotide synthesis, the pathway favors production of ribose-5-phosphate, whereas in tissues prioritizing reductive biosynthesis (like adipose or liver), the focus shifts toward maximizing NADPH output. This metabolic flexibility is key to the PPP’s integration with glycolysis and the cell’s energy state. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #PentosePhosphatePathway #Metabolism Mon, 13 Apr 2026 20:43:14 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/a429354a-9165-46a6-b36c-1517e8b3665e All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.