https://stream.echo6.co/videos/watch/b41bd439-8303-498a-8bef-9bfabe5b145f Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this respiratory physiology lecture, Professor Zach Murphy breaks down the body’s acute and chronic adaptations to high-altitude environments, where barometric pressure and oxygen availability are significantly reduced. This lecture helps you understand how the respiratory system compensates to maintain oxygen delivery under hypoxic conditions. We begin by examining how the partial pressure of oxygen (PaO₂) decreases with altitude and how this leads to hypoxemia and triggers an immediate increase in ventilation (hyperventilation) via activation of peripheral chemoreceptors. You’ll learn how this compensatory hyperventilation causes respiratory alkalosis, and how the kidneys gradually respond by excreting bicarbonate to restore pH balance. The lecture then explores long-term acclimatization, including increased erythropoietin (EPO) production for enhanced RBC mass, angiogenesis, and mitochondrial efficiency, all of which help optimize oxygen delivery and utilization over time. We also discuss clinical considerations such as acute mountain sickness, high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE)—including their pathophysiology, symptoms, and management. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #RespirationAtHighAltitudes #Respiratory Wed, 15 Apr 2026 09:23:30 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/b41bd439-8303-498a-8bef-9bfabe5b145f All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.