https://stream.echo6.co/videos/watch/b8336ac5-049d-405a-8e2d-f96a19047e5f Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this neuropathology lecture, Professor Zach Murphy presents a high-yield discussion of Transverse Myelitis, an acute inflammatory disorder of the spinal cord that results in motor, sensory, and autonomic dysfunction below the level of injury. This lecture ties together immunologic mechanisms, neuroanatomy, and real-world diagnostic reasoning to help you master this critical spinal cord syndrome. We begin by reviewing the pathophysiology of transverse myelitis, which involves immune-mediated inflammation across one or more spinal cord segments. You’ll learn about the idiopathic form as well as secondary causes—including post-infectious, autoimmune, and paraneoplastic syndromes—and its associations with conditions like multiple sclerosis, neuromyelitis optica (NMO), and MOG antibody-associated disease. The lecture covers hallmark clinical findings such as rapidly progressive bilateral motor weakness, sensory deficits, and autonomic dysfunction, including urinary retention and bowel changes. We highlight the classic sensory level on the exam and how lesion location along the spinal cord influences symptoms. You’ll learn the stepwise diagnostic approach using spine MRI, CSF analysis, and serologic testing for NMO and MOG antibodies. We review acute treatment strategies, including high-dose IV corticosteroids and escalation to plasmapheresis or IVIG when patients are steroid-refractory. We also discuss prognosis and long-term considerations, such as recurrence risk and rehabilitation. Enjoy the lecture and support us below! Table of Contents: 0:00 Lab 0:24 Etiology and Pathophysiology 9:36 Clinical Features 15:24 Diagnosis 18:46 Treatment 21:38 Prevention 23:50 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #transversemyelitis #neurology Mon, 13 Apr 2026 20:42:45 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/b8336ac5-049d-405a-8e2d-f96a19047e5f All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.