https://stream.echo6.co/videos/watch/e74151f4-be34-464e-9059-2b8b0b7c68dd Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this cardiovascular physiology lecture, Professor Zach Murphy explores hypertension's mechanisms, breaking down how blood pressure becomes chronically elevated and the systems responsible for regulating it. This session connects core physiological principles with the pathogenesis of one of the most common and impactful cardiovascular conditions. We begin by reviewing the major determinants of blood pressure—cardiac output (CO) and total peripheral resistance (TPR)—and how long-term dysregulation of these variables contributes to sustained elevations in pressure. Zach then walks through key contributors to hypertension, including increased sympathetic tone, impaired renal sodium handling, arteriolar vasoconstriction, and vascular remodeling. We examine how chronic activation of the renin-angiotensin-aldosterone system (RAAS) and inappropriate levels of antidiuretic hormone (ADH) play a central role in maintaining elevated vascular resistance and fluid retention. The lecture highlights endothelial dysfunction, natriuretic peptides, and baroreceptor resetting as additional contributors. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #bloodpressure #hypertension Wed, 15 Apr 2026 11:11:56 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/e74151f4-be34-464e-9059-2b8b0b7c68dd All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.