https://stream.echo6.co/videos/watch/eec83fe4-01c1-4bba-b2f1-08fefe6c0b83 Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy explains the Regulation of Glucose Metabolism, highlighting how the body precisely controls glucose production during fasting and stress. This lecture builds on your understanding of the gluconeogenic pathway by focusing on the hormonal, allosteric, and transcriptional mechanisms determining when and how glucose is synthesized from non-carbohydrate sources. We review the four key bypass enzymes—pyruvate carboxylase, PEP carboxykinase, fructose-1,6-bisphosphatase, and glucose-6-phosphatase—and examine how their activity is regulated at multiple levels. You’ll learn how glucagon and cortisol stimulate gluconeogenesis by promoting enzyme expression and activating cAMP-PKA signaling, while insulin inhibits the process by suppressing transcription and promoting dephosphorylation. We then explore allosteric regulation, emphasizing how high acetyl-CoA, ATP, and citrate levels signal sufficient energy availability and activate key enzymes. AMP and fructose-2,6-bisphosphate act as potent inhibitors to prevent overproduction. Special attention is given to the reciprocal regulation of glycolysis and gluconeogenesis, highlighting how the liver avoids futile cycling between these opposing pathways. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #GluconeogenesisRegulation #Metabolism Wed, 15 Apr 2026 13:28:40 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://stream.echo6.co https://stream.echo6.co/client/assets/images/icons/icon-512x512.png https://stream.echo6.co/videos/watch/eec83fe4-01c1-4bba-b2f1-08fefe6c0b83 All rights reserved, unless otherwise specified in the terms specified at https://stream.echo6.co/about and potential licenses granted by each content's rightholder.